I have the V46 with the F800GS model specific mounting plate.
I do not have side panniers and do not know which ones are compatible. I am guessing there would be more compatibility with the 250 mounting plate since it will mount to most any rear rack.
My V46 has been thru 4 bikes. It has been dropped several times, both on its own and attached to bikes that fell over for one reason or another. It was also on my Multistrada when I totaled it about 30 miles north of the Grand Canyon North rim.
It still works great and is still water proof.