A 'stage 1' mod (air, jetting/FI adj., exhaust) will always make a difference in performance but fuel economy will suffer and you will probably be environmentally unfriendly at that point (if that matters to ya...). All in all I am getting away from running my bikes like this the older I get. If you need more power buy a bigger displacement machine!
'09 HD FLTR
He is no fool who gives what he cannot keep to gain what he cannot lose.