Check the oil, check the oil, check the oil.
Every KLR uses oil at interstate speeds, and especially if you are running harder (into a head wind, or heavily loaded) At 55-60, it's almost never a problem. Over 65-70, I add a couple drops at every stop. I stop every 50-75 miles, just for circulation.
Make sure the rear shock is maxed out on the preload setting.
I used to commute between offices in Massachusetts, Jersey and Harrisburg PA. I'd definately run the parkways instead of the interstates.
Keep tire pressures UP, there's a lot of heat in the road, and overloaded really increases failure rates. More pressure=cooler tire temps.
"Beauty sleep?" Bitch, you don't need a nap, you need to HIBERNATE!