Yesterday I mounted my CL-850's on my S10. Looks fantastic.
On my old Strom you had the same problem as now on the S10. Exhaust on one side, so the soft luggage needs support on the other.
On the Strom I fixed that using the Dan Vesel Soft Luggage Guard (and a couple of Tool Tubes)
On the S10, I opted for the SW Motech Quicklock EVO Rack. Install is a breeze. The backbrace uses the license plate holder. I have the Touratech mudguard on there, and even then it installed without a fuss.
I then added the CL850's. Strapped right down, and the top straps can go under the passenger seat no problem!
Added the Givi Trekker 46L Top Box and I think my luggage setup is complete!
Feel free to ask any questions!