It is most certainly possible...
Just be prepared for this:
And when you DO make it through, plan ahead for many of these:
I have gps tracks for the portion from the Colorado River to Baker (can also be found elsewhere). I also put the mileages and notes into RBEditor to make a roadbook. I highly recommend reading the guidebook: http://www.desertusa.com/web_cart/db/pages/5094.html
"I don't know what you do, but I know what I do, and I don't do that." --Uncle Doug, R.I.P.
"Without the possibility of death, adventure is not possible"--Reinhold Messner
Cpt. Ron screwed with this post 10-30-2012 at 04:32 PM
Reason: Added info.