I have a 48 and the forward controls can make it a bit uncomfortable after 100 or so miles. I installed passenger pegs which I usually use on the highway to put my feet under me. I haven't had any regrets about the forward controls and they are perfect for under 100 mile trips.
A feature of the 48 is the tank is so small, that when you start to feel discomfort, you have to stop for gas.
This said, I'm relatively in shape and in my late 20s so mileage will vary if you are putting a ton of weight on your spine from above.
2013 HD '48