Just make sure your jetting, fuel mix ratio, and gearing is right and you are good to go. If I am rising hwy (100 km/h plus) I am running 14/41. For all the other times I am running 13/41. My friend on his KTM 300 is running 15/52 for hwy runs and 14/52 for local dirt ripping. For me the 14/41 on the hwy is great, very smooth and puts me in the bottom end of 5th. There is stil a ton of jam left if I need to pass.
Have fun with it on the road. Personally I enjoy it a ton, but that is just me ;)
TS 250 KSM