What Solace said. Marietta is a great place to base out of. Stay at the Lafayete Hotel downtown. Can't go wrong with any of the roads down here. Also the roads right accross the river are great too. By the way there are a lot nicer roads than 555 but i tdoes go clear from rte7 to Zanesville. The highways in Wayne National Forest are all great and if you do back roads they're even better.
I'd rather be knee deep in a creek pulling a rock out from underneath your bike. : My wife