I third Marietta. Stayed their last year. From Marietta, the roads south and north east are the best. You can connect between Route 7 (ohio river) and Rt 26 all the way north east to Wheeling. Be careful, these roads are extremely curvy and have crazy elevation changes... sometimes mid corner. Our trip last year we had a guy go down on 255.
The ride south is equally as curvy but much more forgiving. Route 16 south and Route 18 north, connect in between. Great stuff.
I found 555 to be lame. As a whole the road is over rated, in poor condition, and has lots of dirt and rock patches from farm equipment. I found the Ohio River valley and the south much better.
While you are in town, check out Parkersburg, WV for cool Ohio River views and eat at the all you can eat buffet in New Martinsville, WV. Damn that place was GOOD!
My .02 cents... enjoy the ride!
[2011 Ninja 1000] - Full Muzzy, PC5, Auto Tune, Butterflies removed, etc
[2009 KTM 250 XCW(e)]
[2004 KTM 525EXC] - Sumo build