I did well last year until the last round where I fell apart. I had Stoner who missed a few rounds, and Melandri wp crashed on 5 out of the last 6 races.
The trick (i think) is balance, but yes you need to look at the schedule and the number of races of each series in the last round.
MotoGP guys are expensive and in the first round they only score 1/2 as many points.
"Remember that an enduro tests the endurance of three things: your machine, your body, and your wits. Only one has to fail to keep you from reaching the finish line." Cycle World March 1966