After the first 100 miles of Oklahoma, get on the highway and haul ass to Boise City and pick the trail back up there. Oklahoma ended up being our trip-ender, too many spills in the silt for Write2ride and she injured her wrists. If I had it to do over again, we would have skipped all the dirt in OK and saved a lot of misery and frustration. All you will miss is a ton of silt, flat tires from nails everywhere, and crazy oil rig traffic.
I wouldn't skip any of MS or Arkansas, but there was some stuff in TN I could have skipped and it wouldn't have hurt my feelings.