Compression is the first wakeup call for sure on these big singles. I have run Wiseco 11:1, 102.4mm which worked well, though it actually calculated out to 10:1 when measured on install which is fine because that is about the upper limit for fuel availability.
After a crankshaft breakage issue I opted for an XR crank which necessitated a new piston. I went with a JE 11:1, 102mm which also calculated out to 10:1. It also works well and runs great, but it is noisier than the wiseco till it warms up.