two of my riding partners ran them on the TAT, allows you to run low pressure and no pinch flats. But I don't like them as one still needs to carry spare tubes in case a tubliss failure. Yes you can carry extra inner bladders which aren't patchable, and if the red hard liner gets a hole you may need that too, which doesn't pack well. tires can't be plugged on sidewall, plus in some cases a puncture will also penetrate the bladder. On a long trip it's still wise to carry tubes as a back up. Also if you bend a rim, need tubes as a backup.Tubliss isn't as easy to find on the road as tubes. $100 per hoop also. IMHO not worth it, aslo need to carry a high pressure pump for the bladder, not sure if one of the electric pumps is up to high PSI.
that being said some people really like tubliss. They do work on the highway just fine.