Set up? I think the entire Index qualifies as "set-up". What works for one person may not be practical, cost effective, useful for the region etc. etc. for another person.
Horses for courses and all that shiz.
In no particular order... Tires, suspension, muffler, rejet, air box, seat, GPS, luggage, risers, grips, oil, filters, tubes, chains, bearing upgrade, sprockets, chain tension, footpegs, damper adjustments, air pressure, rim locks, grease, brake pads, side stands, center stand EZ-Ups, hydraulic clutches, lighting, service, maintinance, leak repair, more leak repair... shall I go on?
Pick something from the list... you probably have a thread (or five) on the subject.