Some new data. The needles at #4 were eventually border lean at sea level and winter temperatures (10C). Therefore, I moved them to #5, switched the slows back to 42 and the mains to 180/182.
My impression so far of the 45 slows is that I don't like them. The 42's (with higher needle position) allow for better throttle control and I guess this happens because they move the slides towards the lighter throttle end of the operation envelop, being inherently a better metering circuit.
All these are with open akras.
If this setting proves to be heavy on mileage, I will move the needles back to #4, compensate with the fuel screws which currently sit at around 2 turns out and live with a little bit of leanness during the winter months.
Happy New Year to All!