I will be trying out the KLX250 this year for some reasonably close camping trips, 400 miles roundtrip weekenders. The addition of an Alaskan Sheepskin D/S seat cover has helped the comfort level of the seat quite well. I use a Wolfman Enduro tankbag and a set of Aerostitch tank panniers as saddlebags. With a smallish duffle strapped to the rear rack. I lowered the bike 2" and fitted Kenda 50/50 D/S tires instead of the Dunlop knobbies, which I felt handled poorly for street use. A WER steering damper calms the twitchy front end, and helps stabilize the bike in the wind. Having the overdrive 6th gear begs the point that this little trailbike can handle trips, as long as 60-65 mph is going to work for you. That's still midrange on the powercurve pace. Most 2 lane blacktop roads are best suited for those speeds, and the bike is very capable on dirt roads.
I think this bike will do fine for lightweight enduro touring. If a person is +6 ft and +250 lbs, maybe not, but I'm ok on it.